Full - Drug report, Montelukast, Asthma Treatment. structure function, metabolism, excretion.

Introduction Asthma is a common upset associated with the respiratory system; it affects peerless in four primary rail children, one in seven teenagers, and one in ten-spot adults in Australia (Bryant et al, 2002). thither argon many mediators involved in the pathogenesis of an asthma attack attack attack attack attack, and the tartness of the symptoms can switch between individuals. There argon several(prenominal) drugs that have been developed to cut through the unsoundness, with differing mechanisms of action such as sympathomimetics, corticosteroids, leukotriene sensory receptor antagonists and mast-cell stabilizers. This case deals with the leukotriene receptor antagonist montelukast. Montelukast has been shown to be peculiarly effective in treating children with both(prenominal) mild persistent asthma and frequent episodic asthma (Knorr et al, 2001; Nat. Asthma Council, 2002), and individuals with aspirin-sensitive asthma (Seale, 1999). It is prone orally as t he sodium salt of this compound (Singulair ware Information, 2003), the structural formula is shown under Pathophysiology of Asthma As already stated, asthma is a disorder of the respiratory system, it occurs when the passage in and out becomes obstructed repayable to reversible bronchoconstricition, chronic inflammation of the epithelium of the airways, and increased mucose secretion (Bryant et al, 2002). There are many factors involved in the pathogenesis of asthma; such as leukotrienes, histamine, prostaglandins and other cytokines. There are two main types of asthma; extrinsic (atopic, allergic) and intrinsic. Extrinsic asthma is triggered by substances that are not normally found in the body such as allergens like pollen, dust mites and livelihood creature fur. Intrinsic is Mechanism of Action of Montelukast Put simply, montelukast is a reversible, competitive antagonist of leukotrienes selective for the CysLT1 receptor. The leukotrienes are products of arachidoni c acid transfiguration by 5-lipoxygenase (B! orgeat et al, 1976), as shown in figure 1; in that location are 5 leukotrienes: LTA4, LTB4, LTC4, LTD4 and LTE4, of which the... If you requirement to get a unspoiled essay, order it on our website: OrderCustomPaper.com

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